2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-125408
    Maresin conjugates in tissue regeneration 1 1784701-61-6 98%
    Maresin conjugates in tissue regeneration 1 (MCTR1) is a potent cytokine of pro-resolving mediating maresin conjugates in tissue regeneration (MCTR), which reduces the inflammatory response and promotes tissue regeneration. Maresin conjugates in tissue regeneration 1 antagonize LTD4-stimulated vascular responses.
    Maresin conjugates in tissue regeneration 1
  • HY-125505
    BI-11634 1622159-00-5 98%
    BI-11634 is a factor Xa inhibitor. BI-11634 is metabolized by CYP3A4 to form one major metabolite and this reaction is inhibited by Quinidine (HY-B1751H) with a Ki of 7 µM.
    BI-11634
  • HY-125615
    DMP 728 methanesulfonate 155158-97-7 98%
    DMP 728 methanesulfonate is a platelet glycoprotein (GP) IIb/IIIa receptor antagonist. DMP 728 methanesulfonate shows dose-dependent antiplatelet and antithrombotic effects. DMP 728 methanesulfonate can be used in the study of effective antithrombotic agents in thromboembolic diseases of coronary and peripheral arteries.
    DMP 728 methanesulfonate
  • HY-125625
    ES 6864 116326-39-7 98%
    ES 6864 is an orally active, competitive inhibitor for human renin, with an IC50 of 6.9 nM and a Ki of 7.3 nM. ES 6864 exhibits high species-specific and enzyme-specific properties. ES 6864 exhibits metabolic stability in rat tissue homogenates. ES 6864 reduces blood pressure in rats and sodium-depleted awake marmosets.
    ES 6864
  • HY-125700
    Baogongteng A 74239-84-2 98%
    Baogongteng A ((-)-Bao Gong Teng A) is an optically active tropane alkaloid with hypotensive and miotic activity, and can be isolated from the Chinese herb Erycibe obtusifolia Benth. Baogongteng A is also a muscarinic agonist. Baogongteng A can be used for cardiovascular and glaucoma research.
    Baogongteng A
  • HY-12593R
    GS967 (Standard) 1262618-39-2 98%
    GS967 (Standard) is the analytical standard of GS967. This product is intended for research and analytical applications. GS967 (GS-458967) is a potent, and selective inhibitor of cardiac late sodium current (late INa ) with IC50 values of 0.13 and 0.21 μM for ventricular myocytes and isolated hearts, respectively.
    GS967 (Standard)
  • HY-126036
    CH-141 78279-88-6 98%
    CH-141 is a peripheral vasodilator, that can be used in hypertension research.
    CH-141
  • HY-126038
    BTS 39542 57410-31-8 98%
    BTS 39542 is an orally active inhibitor for Na+ K+ Cl cotransport system, that exhibits diuretic activity, and can be used in hypertension and edema research.
    BTS 39542
  • HY-126039
    L-739758 168157-33-3 98%
    L-739758 is an antagonist for αIIbβ3 integrin (platelet glycoprotein IIb/IIIa). L-739758 acts as a peptidomimetic, binds to αIIbβ3 integrin by mimicking the interaction of the RGD (arginine-glycine-aspartic acid) motif, and is involved in the blood coagulation process. L-739758 inhibits platelet aggregation, and is used for thrombosis research.
    L-739758
  • HY-126182
    Deacetyldiltiazem 42399-40-6 98%
    Deacetyldiltiazem is a metabolite with coronary vasodilator activity. Deacetyldiltiazem is present in the plasma of individuals taking Diltiazem. The deacetylase activity of deacetyldiltiazem is mainly catalyzed by the rat Ces2a enzyme. In vitro experiments of deacetyldiltiazem showed that its Km value was similar to that of rat liver microsomes, showing efficient deacetylase activity. The study of deacetyldiltiazem helps to understand the differences in the metabolic kinetics of compounds between different species.
    Deacetyldiltiazem
  • HY-126206
    Quazodine 4015-32-1 98%
    Quazodine is a Phosphodiesterase (PDE) inhibitor. Quazodine can be used in vascular smooth muscle related research.
    Quazodine
  • HY-12654R
    Molidustat (Standard) 1154028-82-6 98%
    Molidustat (Standard) is the analytical standard of Molidustat. This product is intended for research and analytical applications. Molidustat (BAY 85-3934) is an orally active inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH) with IC50 values of 480 nM, 280 nM, and 450 nM for PHD1, PHD2, and PHD3, respectively. Molidustat can elevate the levels of circulating erythropoietin (EPO) to near-normal physiological ranges. Molidustat can be utilized in the research of renal anemia.
    Molidustat (Standard)
  • HY-126645
    Atelopidtoxin 9061-57-8 98%
    Atelopidtoxin (zetekitoxin) is a toxin (LD50=0.016 mg/kg for mice), which can be isolated from Panamanian frog Atelopus zeteki. Atelopidtoxin causes hypotension and ventricular fibrillation in rabbits. Atelopidtoxin an inhibitor for sodium channel.
    Atelopidtoxin
  • HY-126936
    MSD-D 182504-18-3 98%
    MSD-D is a potent and frequency-dependent Kv1.5 channel inhibitor with an IC50 value of 0.5 μM. MSD-D is promising for research of atrial-selective class III antiarrhythmics.
    MSD-D
  • HY-127010
    Arnolol 87129-71-3 98%
    Arnolol is a beta blocker with a pressure-lowering action.
    Arnolol
  • HY-127113
    Q8 1541762-55-3 98%
    Q8, an effective antiangiogenic drug, is a CysLt1 antagonist (IC50 of 4.9 μM). Q8 is sufficient to reduce cellular levels of NF-κB and calpain-2 and secreted levels of the proangiogenic proteins intercellular adhesion molecule-1, vascular cell adhesion protein-1, and VEGF.
    Q8
  • HY-12760R
    Indoramin (Standard) 26844-12-2 98%
    Indoramin (Standard) is the analytical standard of Indoramin. This product is intended for research and analytical applications. Indoramin is an orally active antihypertensive agent. Indoramin is also selective for the α1A-adrenoceptor.
    Indoramin (Standard)
  • HY-12765R
    Losartan Carboxylic Acid (Standard) 124750-92-1 98%
    Losartan Carboxylic Acid (Standard) is the analytical standard of Losartan Carboxylic Acid. This product is intended for research and analytical applications. Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[4].
    Losartan Carboxylic Acid (Standard)
  • HY-12804R
    VAS2870 (Standard) 722456-31-7 98%
    VAS2870 (Standard) is the analytical standard of VAS2870. This product is intended for research and analytical applications. VAS2870 is a NADPH oxidase (NOX) inhibitor.
    VAS2870 (Standard)
  • HY-128090
    Apstatin 160470-73-5 98%
    Apstatin is a potent aminopeptidase P (APP) inhibitor with Ki values of 2.6, 0.64 µM for rat and human APP, respectively. Apstatin shows cardioprotection.
    Apstatin
Cat. No. Product Name / Synonyms Application Reactivity